Scientist I - LNP formulation development Onsite in South San Francisco, CA 1 year initial contract Hourly Pay Rate: $37-40/hr (individual medical benefits available at a cost) Our global pharmaceutical client's growing Genetic Medicine group at their South San Fransisco hub is seeking a highly motivated Associate Scientist to apply cutting-edge technologies to deliver innovative new therapies.
As an integral member of the Genetic Medicine Group, this individual will assist in activities related to lipid nanoparticle (LNP)-mRNA production, process development/optimization, and characterization. The successful candidate will have familiarity with or prior exposure to laboratory instrumentation/methods related to LNP formulation development, such as microfluidic mixers, dynamic light scattering, membrane-based filtration/dialysis, and fluorescent plate-based assays. The successful candidate is expected to either show potential in or have hands-on experience to produce and evaluate LNPs with the aim of supporting pipeline projects as well as supporting general laboratory activities. As one of the key team members this individual will work with the manager and scientists across different functional groups to help discover and develop next generation non-viral genetic medicine. The candidate will need to have excellent verbal and written skills and the ability to clearly present scientific concepts and results.
Key Responsibilities:
- Assist in production and characterization of mRNA-LNP formulations to support internal programs.
- Assist in lipid and reagent preparation for manufacturing process as well as aliquoting and accurate labeling for storage and subsequent stability analysis.
- Familiarity with analytical techniques including but not limited to DLS, HPLC, ELISA, SEC, bioconjugation and nucleic acid characterization.
- Work closely with manager and cross-functional team members on multiple projects simultaneously to collect and analyze data on a per project basis.
- Under manager's supervision, interpret, summarize experimental data, and present experimental results at meetings as needed.
- Assist in ordering supplies and reagents from internal inventory and external vendors necessary to support the projects.
- Generate reliable and reproducible data in a timely manner. Read and adapt scientific literature to accomplish assignments.
- Maintain documentation, databases and laboratory electronic notebooks in compliance with the Company Laboratory Notebook Policy.
- Remain compliant with all departmental and corporate training.
Key Qualifications:
- BS or MS in Chemistry, Chemical Engineering, Biological Engineering, Pharmaceutical Science or a related field with a minimum of 0-2 years of relevant industry experience. Experience with nanoparticle design and characterization methods is preferred.
- Self-motivated, hard-working, detail-oriented, resourceful, and able to work in a fast-paced team environment.
- Good computer skills including Word, Excel, PowerPoint, and relevant scientific software such as Prism.
- Hands-on experience with nucleic acid characterization and nanoparticle formulation is a plus.
- Hands on experience with chemical conjugation to lipid and analytics is a plus.
- Having a basic understanding of immunology and cancer biology is a plus.
Our role in supporting diversity and inclusion
As an international workforce business, we are committed to sourcing personnel that reflects the diversity and values of our client base but also that of Orion Group. We welcome the wide range of experiences and viewpoints that potential workers bring to our business and our clients, including those based on nationality, gender, culture, educational and professional backgrounds, race, ethnicity, sexual orientation, gender identity and expression, disability, and age differences, job classification and religion. In our inclusive workplace, regardless of your employment status as staff or contract, everyone is assured the right of equitable, fair and respectful treatment.
